Australian Streptokinase Trial "ASK"


Phase 3 Results

Eligibility Criteria

Inclusion Criteria

Between the ages of 18 and 85, acute ischemic stroke presenting within 4 hours of onset.

Exclusion Criteria

Mild neurological deficit, anticoagulants given within 48 hours of stroke onset, streptokinase given for reasons other than stroke within the previous 12 months, acute stroke occurring within the previous 3 months, previous stroke present in the same hemisphere that might interfere with the neurological assessment, active peptic ulcer disease, major trauma within the preceding 3 months or surgery within the previous 10 days, pregnancy, childbirth within the past 4 weeks, uncontrolled hypertension, severe systemic disease with poor prognosis, proliferative diabetic retinopathy, or recovery prior to registration of a neurological deficit with a CNS greater than 9.0.