Atrial Fibrillation (AF) Patients Not Taking Vitamin-K Antagonist (VKA)


Phase 2 Results

Eligibility Criteria

Inclusion Criteria

- Either one of the following risk factors is sufficient for inclusion (high risk patient)
- Previous cerebral ischaemic attack (stroke or transient ischaemic attack (TIA), >30 days prior to randomization)
- Previous systemic embolism or at least one of the following risk factors are needed for inclusion: Age ≥75 years
- Symptomatic congestive heart failure
- Impaired left ventricular systolic function
- Diabetes mellitus; Hypertension requiring anti-hypertensive treatment
- In addition to AF the patient must be appropriate for but unable or unwilling to take VKA therapy

Exclusion Criteria

- Presence of a clinically significant valvular heart disease;; Stroke or TIA and/or systemic embolism within the previous 30 days prior to randomization
- Conditions associated with increased risk of major bleeding