Atherosclerosis in High Risk Population Groups: An Assessment by Magnetic Resonance Imaging


Phase 4 Results N/A

Eligibility Criteria

Inclusion Criteria

- Age 22 and above with prior head and neck or chest irradiation
- Six months or more post head and neck irradiation
- Documented subclinical cardiovascular disease (inflammatory markers in the serum)
- Pre-existing plaques [detected by ultrasound, CT or MRI]
- Asymptomatic major arterial stenosis
- Not being considered for arterial surgery or endovascular treatment.

Exclusion Criteria

- Recurrence of cancer (with or without treatment)
- Planned surgical or endovascular intervention for revascularization of carotid arteries at the time of enrollment
- Renal failure
- eGFR < 45 (calculation based on serum creatinine levels, race, age and gender)
- Medically unstable or hematologic, renal, or hepatic dysfunction
- Non-atherosclerotic arterial stenosis (dissection)
- Presence of stents or external clips that can cause artifacts impairing accurate interpretation of MRI data
- Contraindications to MRI: cardiac pacemaker, metal implants, metal in eyes, pregnant or nursing women, claustrophobia, allergy to MRI contrast
- Physical or mental impairment that would limit the patient's ability to comply with the medical instructions or study procedures