Asymptomatic Carotid Atherosclerosis Study "ACAS"

Completed

Phase 3 Results

Trial Description

To determine whether the addition of carotid endarterectomy to aggressive medical management can reduce the incidence of cerebral infarction in patients with asymptomatic carotid artery stenosis.

Interventions

  • Endarterectomy, carotid (CEA)Procedure/Surgery
    Intervention Desc: Surgical therapy to remove atherosclerotic plaque in narrowed carotid arteries.

Trial Design

Prospective, randomized, multicenter trial of 1662 patients at 39 centers.

Patient Involvement

Daily aspirin administration and medical risk factor management for all patients, carotid endarterectomy for patients randomized to receive surgery. Patients were followed for

Outcomes

Type Measure Time Frame Safety Issue
Primary Cerebral infarction occurring in the distribution of the study artery or any stroke or death occurring the perioperative period.