Association of Apolipoprotein B-48 Level and Large arterY Atherosclerotic iSchemic Stroke(ABYSS)

Recruiting

Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

Large artery atherosclerotic ischemic stroke group(LAA group)
- Age over 20 years
- Patients with symptomatic stenosis in the eligible vessels(the middle cerebral artery, anterior cerebral artery, or internal carotid artery) as assessed by MRA or CTA corresponding to the acute ischemic stroke
- Patients without the occlusion of corresponding artery by MRA or CTA
- The fasting and postprandial serum Apo B-48 level can be assessed within 72 hours after the symptom onset of ischemic stroke
Small vessel occlusive ischemic stroke group (SVO group)
- Age over 20 years
- Patients with acute ischemic stroke of basal ganglia, internal capsule, or corona radiata
- Patients without both symptomatic and asymptomatic arterial occlusion or stenosis by MRA or CTA
- Patients without a history of systemic atherosclerosis(for example, acute myocardial infarction, angina, peripheral arterial disease, aortic aneurysm)
- The fasting and postprandial serum Apo B-48 level can be assessed within 72 hours after the symptom onset of ischemic stroke
Exclusion Criteria: both LAA group and SVO group
- Patients with cardioembolic ischemic stroke
- Patients treated with lipid lowering agents or steroid within the previous 30 dsys
- Patients with severe liver disease (AST >100 or ALT >100) at the time of randomization
- Patients with endocrine disease except diabetes mellitus at the time of randomization (for example, thyroid disease, adrenal disease)
- Patients with severe renal disease (serum creatinine >2.0mg/dl)at the time of randomization
- chronic alcoholics or drug user
- Patients with infection at the time of randomization
- Patients, in the opinion of the investigator, unlikely to comply with the clinical study or unsuitable for the any other disease or reason
- Informed consent has not been obtained