To study the role of acetylsalicylic acid in patients undergoing carotid endarterectomy.
- Aspirin (stroke prevention) Drug
Intervention Desc: Antiplatelet agent; inhibits thromboxane A2
- Endarterectomy, carotid (CEA)Procedure/Surgery
Intervention Desc: Surgical therapy to remove atherosclerotic plaque in narrowed carotid arteries.
Randomized, double-blind, controlled trial of 2849 patients at 74 centers.
Patients were randomly assigned 81 mg (n=709), 325 mg (n=708), 650 mg (n=715), or 1300 mg (n=717) acetylsalicylic acid daily, started before surgery and continued for 3 months.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Stroke, myocardial infarction, and death measured at 30 days and 3 months.|