Aspirin and Carotid Endarterectomy Trial "ACE"


Phase N/A Results

Trial Description

To study the role of acetylsalicylic acid in patients undergoing carotid endarterectomy.


Trial Design

Randomized, double-blind, controlled trial of 2849 patients at 74 centers.

Patient Involvement

Patients were randomly assigned 81 mg (n=709), 325 mg (n=708), 650 mg (n=715), or 1300 mg (n=717) acetylsalicylic acid daily, started before surgery and continued for 3 months.


Type Measure Time Frame Safety Issue
Primary Stroke, myocardial infarction, and death measured at 30 days and 3 months.


National Institute for Neurological Disorders and Stroke, NIH