Asian Botulinum Clinical Trial Designed for Early Stroke Spasticity


Phase 4 Results N/A

Eligibility Criteria

Inclusion Criteria

- First-ever stroke according to the World Health Organisation criteria (previous transient ischaemic attack or clinically silent infarct on CT/MRI is not counted as previous stroke)
- CT/MRI scan required to classify ischaemic / haemorrhagic stroke
- Patient recruited 2-12 weeks after stroke
- Modified Ashworth Spasticity Score 1+ or above in either elbow or wrist joint

Exclusion Criteria

- The patient has bleeding disturbances or having used coumarin derivatives
- The patient is currently receiving drugs affecting neuromuscular transmission
- Co-existing severe systemic illness which may adversely affect the functional outcome
- Pre-existing neuromuscular junction disease or any neurogenic disorders which can interfere with spasticity