To compare the long-term benefits of lowering cholesterol in hypertensive patients for the prevention of coronary heart disease and stroke.
- Atorvastatin (Lipitor®)Drug
Other Names: Lipitor Intervention Desc: Competitive inhibitor of HMG-CoA reductase; lowers cholesterol and lipids
Multicenter, double-blind randomized subset of the ASCOT trial.
Patients were randomly assigned to receive either 10mg atorvastatin (n=5168) or placebo (n=5137) daily.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Assess and compare the long-term effects of statin vs placebo on non-fatal myocardial infarction, silent myocardial infarction, and fatal coronary heart disease.|
|Secondary||All causes of mortality, fatal and non-fatal stroke, fatal and non-fatal heart failure, total coronary endpoints, and total cardiovascular events.|