To determine whether clopidogrel compared with aspirin would be particularly efficacious in preventing ischemic events in diabetic patients with atherosclerosis.
- Aspirin (stroke prevention) Drug
Intervention Desc: Antiplatelet agent; inhibits thromboxane A2
- Clopidogrel (Plavix®)Drug
Other Names: Plavix, Clodelib, Clovelen Intervention Desc: Antiplatelet agent
Randomized, double-blinded, controlled clinical trial.
All patients were randomized to either clopidogrel (1,914) or aspirin (1,952) treatment groups. All analyses were performed on an on-treatment basis, with each patient’s time at risk censored 28 days after early discontinuation of the study drug.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Vascular death, all-cause stroke, MI, or rehospitalization for ischemia or bleeding.|