Amphetamine and Physiotherapy after Stroke


Phase N/A Results

Trial Description

To investigate the effect of 10 sessions of an oral dose of amphetamine combined with physiotherapy on rehabilitating stroke patients, starting 5–10 days after stroke.


Trial Design

Randomized, double-blind, placebo-controlled clinical trial.

Patient Involvement

Drug treatment was given in the form of identical white tablets of 2 x 5 mg of either d,l-amphetamine or placebo60 min before the training session. All patients underwent at least 30 min of physiotherapy 5 days a week in addition to the ward’s regular training program.


Type Measure Time Frame Safety Issue
Primary The FM motor performance score was used to evaluate changes in motor function. Motor function and activities of daily living (ADL) were assessed by a physiotherapist (L.S.) at baseline, at the end of the 10th session and at follow-up, 3 months after stroke.