Allogeneic Genoidentical Stem Cell Transplantation in Children With Sickle-cell Anemia and Cerebral Vasculopathy "DREPAGREFFE"

Completed

Phase N/A Results N/A

Update History

3 Dec '15
The description was updated.
New
The aim of this study is to demonstrate that cerebral velocities assessed by transcranial doppler (TCD)are more significantly decreased by SCT than by long-term transfusion program A multicenter, national, non-randomized, prospective study of paired cohort will be conducted, with 2 groups of exposed (SCT) and non-exposed (TP) patients. Sixty-three patients will be enrolled, namely 21 sickle-cell patients in the "SCT" group and 42 in the "Transfusion Program (TP)" group
Old
The aim of this study is to demonstrate that cerebral velocities assessed by transcranial doppler (TCD)are more significantly decreased by SCT than by long-term transfusion program A multicenter, national, non-randomized, prospective study of paired cohort will be conducted, with 2 groups of exposed (SCT) and non-exposed (TP) patients. Sixty-three patients will be enrolled, namely 21 sickle-cell patients in the "SCT" group and 42 in the "Transfusion Program (TP)" group
The eligibility criteria were updated.
New
Inclusion Criteria: - Sickle cell anemia patients (SS/Sb0) - < 15 years old - History of abnormal transcranial doppler (TCD) (≥ 200 cm/sec) - Siblings from the same parental couple - Parents amenable to Human Leucocyte Antigen (HLA) typing, SCT if an HLA-identical sibling is available or to long-term transfusion program Exclusion Criteria: - Sickle cell patients older than 15 years - no history of abnormal transcranial doppler (TCD) (≥ 200 cm/sec) - no sibling from the same parental couple - parents averse to HLA typing, SCT if an HLA-identical sibling is available or to long-term transfusion program
Old
Inclusion Criteria: - Sickle cell anemia patients (SS/Sb0) - < 15 years old - History of abnormal transcranial doppler (TCD) (≥ 200 cm/sec) - Siblings from the same parental couple - Parents amenable to Human Leucocyte Antigen (HLA) typing, SCT if an HLA-identical sibling is available or to long-term transfusion program Exclusion Criteria: - Sickle cell patients older than 15 years - no history of abnormal transcranial doppler (TCD) (≥ 200 cm/sec) - no sibling from the same parental couple - parents averse to HLA typing, SCT if an HLA-identical sibling is available or to long-term transfusion program
17 Oct '13
A location was updated in Créteil.
New
The overall status was removed for CHIC.
21 Nov '12
The eligibility criteria were updated.
New
Inclusion Criteria: - Sickle cell anemia patients (SS/Sb0) - < 15 years old - History of abnormal transcranial doppler (TCD) (≥ 200 cm/sec) - Siblings from the same parental couple - Parents amenable to Human Leucocyte Antigen (HLA) typing, SCT if an HLA-identical sibling is available or to long-term transfusion program Exclusion Criteria: - Sickle cell patients older than 15 years - no history of abnormal transcranial doppler (TCD) (≥ 200 cm/sec) - no sibling from the same parental couple - parents averse to HLA typing, SCT if an HLA-identical sibling is available or to long-term transfusion program
Old
Inclusion Criteria: - Sickle cell anemia patients (SS/Sb0) - < 15 years old - History of abnormal transcranial doppler (TCD) (≥ 200 cm/sec) - Siblings from the same parental couple - Parents amenable to HLA typing, SCT if an HLA-identical sibling is available or to long-term transfusion program Exclusion Criteria: - Sickle cell patients older than 15 years - no history of abnormal transcranial doppler (TCD) (≥ 200 cm/sec) - no sibling from the same parental couple - parents averse to HLA typing, SCT if an HLA-identical sibling is available or to long-term transfusion program
6 Oct '11
The eligibility criteria were updated.
New
Inclusion Criteria: - Sickle cell anemia patients (SS/Sb0) - < 15 years old - History of abnormal transcranial doppler (TCD) (≥ 200 cm/sec) - Siblings from the same parental couple - Parents amenable to HLA typing, SCT if an HLA-identical sibling is available or to long-term transfusion program Exclusion Criteria: - Sickle cell patients older than 15 years - no history of abnormal transcranial doppler (TCD) (≥ 200 cm/sec) - no sibling from the same parental couple - parents averse to HLA typing, SCT if an HLA-identical sibling is available or to long-term transfusion program
Old
Inclusion Criteria: - Sickle cell anemia patients (SS/Sb0) - < 15 years old - History of abnormal transcranial doppler (TCD) (? 200 cm/sec) - Siblings from the same parental couple - Parents amenable to HLA typing, SCT if an HLA-identical sibling is available or to long-term transfusion program Exclusion Criteria: - Sickle cell patients older than 15 years - no history of abnormal transcranial doppler (TCD) (? 200 cm/sec) - no sibling from the same parental couple - parents averse to HLA typing, SCT if an HLA-identical sibling is available or to long-term transfusion program