AdminiStration of Statin On Acute Ischemic stRoke patienT Trial "ASSORT"

Recruiting

Phase 4 Results N/A

Trial Description

Investigators will study whether immediate statin treatment after the onset of stroke is beneficial on the neurological protection

Detailed Description

It is much more important in Japan than Western to improve the prognosis after stroke because the prevalence and mortality rate of stroke in Japan is about 3-4 times as those of acute myocardial infarction. Investigators will study whether immediate statin treatment after the onset of stroke is beneficial on the neurological protection since most of previous studies with statins just showed the preventive effects from onset of primary or recurrent cerebral infarction.

Conditions

Interventions

  • Statin Drug
    Other Names: Pre-existing statin regimen
    Intervention Desc: Randomized controlled trial of early versus late statin therapy in patients with ischemic stroke
    ARM 1: Kind: Experimental
    Label: Acute Group
    Description: Atorvastatin 20 mg or Pitavastain 4 mg or Rosuvastatin 5 mg treatment initiated within 24 hours after admission
    ARM 2: Kind: Experimental
    Label: Stable Group
    Description: Not start or withdraw Atorvastatin 20 mg or Pitavastain 4 mg or Rosuvastatin 5 mg treatment for a weak after admission.

Trial Design

  • Allocation: Randomized
  • Masking: Single Blind (Outcomes Assessor)
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary modified Rankin Scale 12 weeks from stroke onset No

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