Investigators will study whether immediate statin treatment after the onset of stroke is beneficial on the neurological protection
It is much more important in Japan than Western to improve the prognosis after stroke because the prevalence and mortality rate of stroke in Japan is about 3-4 times as those of acute myocardial infarction. Investigators will study whether immediate statin treatment after the onset of stroke is beneficial on the neurological protection since most of previous studies with statins just showed the preventive effects from onset of primary or recurrent cerebral infarction.
- Statin Drug
Other Names: Pre-existing statin regimen Intervention Desc: Randomized controlled trial of early versus late statin therapy in patients with ischemic stroke ARM 1: Kind: Experimental Label: Acute Group Description: Atorvastatin 20 mg or Pitavastain 4 mg or Rosuvastatin 5 mg treatment initiated within 24 hours after admission ARM 2: Kind: Experimental Label: Stable Group Description: Not start or withdraw Atorvastatin 20 mg or Pitavastain 4 mg or Rosuvastatin 5 mg treatment for a weak after admission.
- Allocation: Randomized
- Masking: Single Blind (Outcomes Assessor)
- Purpose: Treatment
- Endpoint: Efficacy Study
- Intervention: Parallel Assignment
|Type||Measure||Time Frame||Safety Issue|
|Primary||modified Rankin Scale||12 weeks from stroke onset||No|