Acute Stroke Program of Interventions Addressing Racial and Ethnic Disparities "ASPIRE"


Phase N/A Results N/A

Trial Description

The purpose of this study is to increase treatment of acute stroke with tissue plasminogen activator (tPA) across the District of Columbia. This study, however, will not evaluate tPA as an intervention.

Detailed Description

There are a number of well-known barriers to receiving tissue plasminogen activator (tPA) including transit time to hospital, paramedic and provider training, tPA standing orders, and provider guidelines. Among underserved populations, limited stroke knowledge, socioculturally determined attitudes, and beliefs and myths held by community members may serve as additional barriers that hinder these populations from receiving tPA and acute stroke care. Targeted multilevel interventions designed to overcome specific barriers may significantly increase the number of individuals with stroke who are appropriately treated with intravenous tPA (IV tPA) in underserved communities. Identification of the specific components of healthcare interventions that are the most effective is critical to improve delivery of acute stroke therapy.
The goal of this study is to learn more about public knowledge, attitudes, beliefs and perceptions regarding stroke and stroke treatment in order to identify sociocultural and environmental barriers to receiving tPA and acute stroke care in an underserved community. This study will also determine if implementation of a multilevel intervention program can significantly increase the number of people with ischemic stroke who are appropriately treated with IV tPA in a predominantly underserved community.
In the study, researchers will evaluate the different levels of the intervention to determine which efforts are most effective.


Trial Design

  • Observation: Ecologic or Community
  • Perspective: Prospective
  • Sampling: Non-Probability Sample

Trial Population

Adult residents of the District of Columbia


Type Measure Time Frame Safety Issue
Primary The proportion of people with ischemic stroke appropriately treated with IV tPA. 4 years No
Secondary Qualitative data collected from the community will identify baseline levels of knowledge, attitudes, and perceived and encountered barriers to acute stroke treatment. 1 year No