Acupuncture Lowering Blood Pressure for Secondary Prevention of Stroke

Recruiting

Phase N/A Results N/A

Trial Description

This study evaluate the effects of acupuncture method on the recurrence of ischemic stroke patients.Half of participants will receive "Huo Xue San Feng" acupuncture combining 1 antihypertensive medication on the routine ischemic stroke treatments' basis. While the other half will receive 1 antihypertensive medication and basic treatments for ischemic stroke.

Detailed Description

Under recuiting 480 patients come from 5 hospitals in China.Eligible patients will be randomly assigned into 2 groups: treatment group and control group. The treatment group will receive "Huo Xue San Feng" acupuncture combining 1 antihypertensive medication on the routine ischemic stroke treatments' basis. The control group will receive 1 antihypertensive medication and basic treatments for ischemic stroke. "Huo Xue San Feng" acupuncture will be given six sessions weekly for the first 6 weeks and three times weekly for the next 6 weeks. A 9-month follow-up will thereafter be conducted. Antihypertensive medications will be adjusted based on BP levels.

Conditions

Interventions

  • Acupuncture Device
    Intervention Desc: "Huo Xue San Feng" acupuncture method: Patients will recieve the acupuncture treatment,choose the bilateral point:Renying(ST9),Hegu(L14),Taichong(LR3),Quchi(LI11),Zusanli(ST36). Routine care for ischemic stroke :patients will recieve the acupuncture treatment,choose the point:Neiguan(PC6),Renzhong(10),Sanyinjiao(SP6),Jiquan(HT1),Chize(LU5),Weizhong(BL40). Drugs: Antihypertensive drugs.Patients will be treated 1 of 5 type of antihypertensive drugs,include ARB、ACEI、βreceptor blocker,CCB,Diuretic. The time of therapy will consist of 6 times per week in Continuous treatment phase(1st-6th week after enrollment) and 3 times per week(once every other day) in Consolidation treatment phase(7th-tewlve week after enrollment)
    ARM 1: Kind: Experimental
    Label: Treatment Group
    Description: Participants will recieve the therapy as follows: "Huo Xue San Feng" acupuncture method+Routine care for ischemic stroke+One type of antihypertensive medication. Intervention:Acupuncture(choosing the bilatral acupoint: Renying(ST9),Hegu(L14), Taichong(LR3),Quchi(LI11),Zusanli(ST36))+Drugs(one type of antihypertensive medicine)

Outcomes

Type Measure Time Frame Safety Issue
Primary The Effects of Acupuncture on Reccurence of Ischemic Stroke 1 year after enrollment
Secondary 24-hour ambulatory blood pressure the first day、6 weeks、12 weeks after enrollment
Secondary Daily Blood Pressure by Electronic Sphygmomanometer 1 year after enrollment
Secondary Antihypertensive Drug Stop/Resumption/Increasing Rate 1 year after enrollment
Secondary Nitric Oxide(NO) the first day、12 weeks,6 months after enrollment
Secondary Endothelin(ET) the first day、12 weeks,6 months after enrollment
Secondary The Cardiac Color Doppler Ultrasonography the first day、12 weeks after enrollment
Secondary Carotid Color Ultrasonography the first day、12 weeks after enrollment
Secondary Brain Color Doppler Ultrasonography the first day、12 weeks after enrollment
Secondary Lower Extremity Color Ultrasonography the first day、12 weeks after enrollment
Secondary TCM syndrome score the first day、6 weeks、12 weeks after enrollment
Secondary Short Form 36-item Health Survey (SF-36) the first day、6 weeks、12 weeks after enrollment
Secondary National Institute of Health stroke scale (NIHSS),as well as Barthel Index (BI) scale the first day、12 weeks after enrollment
Secondary Essen stroke risk score (ESRS) the first day、1 year after enrollment
Secondary All-caused Morality 1 year after enrollment
Secondary Serum homocysteine(Hcy) the first day、12 weeks,6 months after enrollment
Secondary Soluble CD40L(sCD40L) the first day、12 weeks,6 months after enrollment
Secondary Copeptin the first day、12 weeks,6 months after enrollment

Sponsors