A Study of the Efficacy and Safety of Alteplase in Participants With Mild Stroke "PRISMS"


Phase 3 Results N/A

Summary of Purpose

PRISMS is a double-blind, multicenter, randomized, Phase IIIb study to evaluate the efficacy and safety of intravenous (IV) alteplase in participants with mild acute ischemic strokes that do not appear to be clearly disabling. Participants will be randomized in a 1:1 ratio to receive within 3 hours of last known well... Trial Stopped: The study was terminated due to slow enrollment.

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 5 July 2017.

31 May 2014 24 Feb 2014 22 Mar 2017 22 Mar 2017 1 Jul 2017 Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Basics

Interventions See All



Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Investigator)
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Parallel Assignment