A sham stimulation-controlled trial of rTMS of the unaffected hemisphere in stroke patients

Completed

Phase N/A Results

Trial Description

To investigate the efficacy of slow-frequency repetitive transcranial magnetic stimulation (rTMS) to the unaffected hemisphere in decreasing interhemispheric inhibition of the lesioned hemisphere and improving motor function in stroke patients.

Interventions

  • Electrical stimulation Other
    Intervention Desc: This category includes any form of electrical stimulation intended to improve motor function or pain after stroke.

Trial Design

Crossover, sham, stimulation-controlled, double-blind study.

Patient Involvement

Participants received three sessions of rTMS (1 Hz, 100% of motor threshold, 600 pulses) to the unaffected hemisphere over the primary motor (real or sham rTMS) and over the premotor cortex (real rTMS). The sessions were randomized and counterbalanced across participants and each session separated by 1 hour to minimize carryover effects.

Outcomes

Type Measure Time Frame Safety Issue
Primary The following tests were run to evaluate the motor function of the affected hand: 1) simple reaction time (sRT), 2) four-choice reaction time (cRT), 3) Purdue Pegboard Test, and 4) finger tapping. Each patient was tested at baseline and after sham, motor, and premotor rTMS.

Sponsors

Harvard Thorndike General Clinical Research Center