A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients "MACH"


Phase 1/2 Results

Eligibility Criteria

Inclusion Criteria

- 18 years of age or older.
- Intracerebral hemorrhage documented by CT scan
- The first dose of the drug can be administered within 12 hours of time last known to be at baseline

Exclusion Criteria

- Allergy to tetracycline antibiotics
- Pregnancy or suspected pregnancy (pregnancy test will be done on women of child-bearing potential)
- Hepatic and/or renal insufficiency (LFT's >3x upper limit of normal; Creatinine >2mg/dL)
- History of intolerance to minocycline
- National Institutes of Health Stroke Scale score of 4 or less
- Glasgow Coma Scale score of 5 or less
- Surgical evacuation of hematoma planned within 24 hours
- Secondary intracerebral hemorrhage resulting from trauma, arteriovenous malformation, aneurysm, tumor or other causes
- Thrombocytopenia (platelet count <75,000/mm3) or coagulopathy (INR >1.4)
- Previously not independent (prestroke modified Rankin scale score >2)
- Suspected of not being able to comply with the study protocol
- Unlikely to be available for 90 day follow-up
- Pre-existing Do Not Resuscitate (DNR) order or indication that a new DNR order will be implemented within the first 48 hours of hospitalization