Trial of EXenatide in Acute Ischaemic Stroke "TEXAIS"


Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- Males and females 18 years or older
- Acute Ischaemic Stroke - CT brain exclusion of haemorrhagic stroke
- Blood glucose level on admission ≥ 4mmol/L
- First trial treatment possible within 9 hours of stroke onset
- Pre-morbid /mRS score of 0-2

Exclusion Criteria

- Haemorrhagic stroke
- Poor clinical prognosis /palliation (considered unlikely to survive beyond 14 days post stroke).
- Any known allergy or hypersensitivity to Exenatide
- Females who are pregnant (known or suspected) or currently breastfeeding
- Any past history of pancreatitis or evidence of active pancreatitis
- Past history of severe gastrointestinal disease (including but not limited to gastroparesis and dumping syndrome)
- Current chronic kidney disease stage 4 or 5 (creatinine clearance <30ml/min)
- Current participation in another investigational drug or interventional trial
- Inability to provide consent (participant or person responsible as local laws apply)