A Brain Centered Neuroengineering Approach for Motor Recovery After Stroke: Combined rTMS and BCI Training

Completed

Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- 18-70 years of age
- Cortical or subcortical stroke with isolated unilateral motor paresis
- At least 3 months but no greater than 12 months post stroke and in stable conditions as judged by patient's physician
- Impaired hand function compared to nonparetic side but at least 10 degrees of active finger extension
- Able to ambulate at least 50 feet with minimal stand-by assistance
- Upper Extremity Fugl Meyer (Fugl-Meyer et al., 1975) score of greater than or equal to 20 out of 66
- Beck Depression Inventory (Beck et al., 1961) less than or equal to 19 out of 63
- Mini-mental State Examination score (Folstein et al., 1975) greater than or equal to 24 out of 30
- Must have an ipsilesional motor-evoked potential (MEP) in response to TMS
- Must be stable outpatients currently undergoing rehabilitation consistent with the current standards of care
- Must be able to communicate clearly in English
- Must be able to provide consent in writing.

Exclusion Criteria

- Personal history of epilepsy or seizures within the past 2 years
- Previous surgical procedure to the spinal cord
- Any MRI incompatible devices
- Pregnancy
- Claustrophobia
- Breathing disorder
- Hearing problems or ringing in the ears
- Bilateral motor paresis or paralysis or those patients that would require significant medical monitoring or management beyond that of a stable outpatient
- Cognitive deficits, other non-motor neurological impairment, bilateral motor paresis or paralysis or those patients that would require significant medical monitoring or management beyond that of a stable outpatient