EC/IC Bypass Study
International Cooperative Study of Extracranial/Intracranial Arterial Anastomosis
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Status:
Trial complete. Results published in November of 1985.
Purpose:
To determine whether anastomosis of the superficial temporal artery to the middle cerebral artery decreases the rate of stroke and stroke-related death among patients with symptomatic disease of the internal carotid and middle cerebral arteries.
Interventions:
STA-MCA bypass
Surgical anastamosis between superficial temporal artery and middle cerebral artery.
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Design:
International, multicenter, randomized trial of 1377 patients.
Inclusion Criteria
One or more transient ischemic attacks or one or more minor completed strokes in the carotid distribution 3 months prior to entry.
Patient Involvement:
714 patients were randomly assigned to the best medical care and 663 to the same regimen with the addition of bypass surgery joining the superficial temporal artery and the middle cerebral artery.
Primary Outcome:
Fatal or nonfatal stroke during mean follow-up period of 55.8 months.
Results:
30-day surgical mortality and major stroke morbidity rates were 0.6% and 2.5%, respectively. The postoperative bypass patency rate was 96%. Nonfatal and fatal stroke occurred both more frequently and earlier in the patients operated on. Patients with severe middle-cerebral-artery stenosis and those with persistence of ischemic symptoms after and internal-carotid-artery occlusion fared substantially worse in the surgical group.
Source of Information:
N Engl J Med 1985 Nov. 7; 313(19):1191-200
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Web Links and Publications:
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This information last updated on: 9/26/2000
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