CAST
Chinese Acute Stroke Trial
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Status:
Trial published 1997.
Purpose:
To study the effects on early mortality and major morbidity of early aspirin treatment in a wide range of stroke patients.
Design:
Randomized, placebo-controlled trial of 21106 patients at 413 Chinese hospitals.
Inclusion Criteria
Acute ischemic stroke presenting within 48 hours of onset. No clear indications for, or contraindications to aspirin.
Patient Involvement:
10,554 patients were randomized to receive aspirin (160 mg/day) and 10,552 received placebo.
Primary Outcome:
Death from any cause during 4-week treatment period and death or dependence at the time of discharge from hospital.
Secondary Outcome:
Fatal or non-fatal recurrent stroke and death or non-fatal stroke.
Results:
There was a significant (14%, SD 7) proportional reduction in mortality and fewer recurrent ischemic strokes (2p=0.01) in patients receiving aspirin during treatment period. At discharge, 11.4 fewer patients per 1000 were dead or dependent (2p=0.08) in the group receiving aspirin.
Source of Information:
Lancet 1997 Jun 7;349(9066): 1641-9
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This information last updated on: 7/28/2008
Reviewed on: 07/28/2008.
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