Stroke Genomics - A Correlative Study of Stroke Subtypes, Neuroimaging, Therapy and Outcome Measures
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Status:
This study has been completed.
Purpose:
To determine if the gene expression profile in white blood cells can be used to fingerprint different stroke subtypes and outcome.
Year Started:
2002
Year Finished:
2009
Inclusion Criteria
HEALTHY VOLUNTEERS: Over age 21; healthy; willing to participate in the study.
ACUTE STROKE PATIENTS: Stroke patients admitted to Suburban or Holy Cross Hospitals; Over age 21; willing to participate in the study.
Exclusion Criteria
HEALTHY VOLUNTEERS: Active medical problems; current symptomatic infection; current severe allergic disorders.
STROKE PATIENTS: Cardiovascular instability; severe anemia (hemoglobin less than 8.0 gm/dl); hemorrhagic diathesis;
current infection; current severe allergic disorders.
Patient Involvement:
Healthy volunteers over age 21 and stroke patients over age 21 who are admitted to the NIH Stroke Program at Suburban Hospital in Bethesda, Md., may be eligible for this study. Volunteers will be screened with a medical history, blood pressure and pulse measurements, electrocardiogram, and neurological examination. Participants will have 20 to 35 milliliters (about an ounce) of blood drawn for genetic studies. The genetic material will be extracted from the white blood cells and analyzed for normal and abnormal gene activity related to stroke. The stroke patients will have sequential samples taken at the time of stroke and during stroke recovery.
Source of Information:
ClinicalTrials.gov
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Web Links and Publications:
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This information last updated on: 10/7/2009
Reviewed on: 10/07/2009.
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