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PubMed
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Stroke Interventions in Clinical Trials
Printable Version
ISGC
International Stroke Genetics Consortium



Principal Investigator
Jonathan Rosand, MD MSc

PI Address
Jonathan Rosand, MD MSc
Massachusetts General Hospital
info@strokegenetics.org www.strokegenetics.org

Contact Email
info@strokegenetics.org



Study Size Planned:24000
Centers Actual:19
Min Age:18
Status:
Ongoing. More centers are welcome to join.

Purpose:
To build an international network of investigators with high quality patient and control samples and subsequently perform genetic studies with adequate power; to perform genome-wide association studies of these patients and controls, with follow-up and replication studies of targeted (regions and) genes.

Year Started: 2007

Design:
A network of international investigators co-operating in genetic stroke research.

Patient Involvement:
Patient and control subjects will have genetic studies done.

Primary Outcome:
To examine the influence of inherited genetic variation on cerebrovascular disease in order to improve the understanding of its pathogenesis and to utilize what we learn to develop novel diagnostic, management, and preventive strategies for individuals affected by stroke and related disorders.

Results:
Analysis will be done using genetic association studies.

Source of Information:
Presented at the 2008 International Stroke Conference (February 2008).

Web Links and Publications:
Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke.
Ann Neurol 2009 May;65(5):531-9

International Stroke Genetics Consortium
http://www.strokegenetics.org/index.html

This information last updated on: 10/30/2009

Reviewed on: 07/07/2009.

UID: 812

   

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