IST
International Stroke Trial
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Status:
Trial complete. Results published in May of 1997.
Purpose:
To assess the safety and efficacy of antithrombotic therapy.
Design:
Randomized, open trial involving 19435 patients.
Inclusion Criteria
Suspected acute ischemic stroke presenting within 48 hours of symptom onset.
Patient Involvement:
Half of the 19,435 participating patients received unfractionated heparin (5000 or 12,500 IU twice daily) and half were told to avoid heparin. In a factorial design, half received aspirin 300 mg daily and half were told to avoid aspirin. Treatment was continued for 14 days or until hospital discharge.
Primary Outcome:
Death within 14 days and death or dependency at 6 months.
Results:
There was no statistically significant difference in death at 14 days, or death or dependence at 6 months between patients receiving heparin vs. no heparin. There was, however, a statistically significant difference in the number of deaths and recurrent strokes between patients receiving aspirin vs. no aspirin after adjustment for baseline prognosis.
Source of Information:
Lancet 1997 May 31;349(9065):1569-81.
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Web Links and Publications:
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This information last updated on: 8/13/2008
Reviewed on: 08/13/2008.
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