Alcohol consumption and risk for stroke among Chinese men
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Status:
Completed. Results published August 2007.
Purpose:
To determine the extent of stroke risk alcohol consumption presents in Chinese men.
Year Started:
1991
Year Finished:
2000
Design:
Prospective cohort study (from the China National Hypertension Survey Epidemiology Follow-up Study).
Inclusion Criteria
A multistage random cluster sampling design was used to select a representative sample of the general Chinese population of men aged 40 years or older at their baseline examination from all 30 provinces in mainland China.
Exclusion Criteria
Men from the sample with a history of stroke at their baseline examination; also those with incomplete alcohol consumption information at followup.
Patient Involvement:
Baseline data were collected at a single clinic visit; data on demographic characteristics, medical history, and lifestyle risk factors were obtained using a standard questionnaire administered by trained staff. Alcohol use was assessed by interviewer-administered questionnaire with six questions regarding regularity, frequency, amount, and type of alcoholic drinks consumed. Information was collected on consumption of liquor, beer, wine, and rice wine. Those who answered yes to the question Do you drink? and provided information on at least one type of alcohol consumed that documented that they drank more than 12 standard drinks per year were defined as drinkers. Those who reported never drinking or consumed less than 12 standard drinks per year were categorized as nondrinkers. Follow-up evaluation was conducted in 1999 to 2000, which included determining vital status, interviewing participants or proxies, and obtaining hospital and medical records (including physical examinations, lab tests, CT scans and any MRI scans, death certificates and autopsy records)for incident and fatal strokes.
Primary Outcome:
Incidence of stroke.
Secondary Outcome:
Analyses by subtype of stroke.
Results:
3,434 incident strokes (1,848 stroke deaths) were documented, giving a relative risk .92 of incidence of stroke among drinkers of 1 to 6 drinks per week (confidence interval 95%), 1.02 among drinkers of 7 to 20 drinks per week, 1.22 among those drinking 21 to 34 drinks per week, and 1.22 risk among those drinking 35 or more drinks per week.
Analyses by subtype of stroke revealed 1,724 (50.2%) were classified as ischemic, 825 (24.0%) were classified as hemorrhagic, 852 (24.8%) were of unknown subtype (not classified as either ischemic or hemorrhagic). 33 were removed from the subtype analyses, due to being classified as both ischemic and hemorrhagic.
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This information last updated on: 8/20/2007
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