ACE
Aspirin and Carotid Endarterectomy Trial
|
Status:
Trial complete. Results published in June of 1999.
Purpose:
To study the role of acetylsalicylic acid in patients undergoing carotid endarterectomy.
Location(s):
U.S., Canada, Australia, Italy, Argentina, Finland
Design:
Randomized, double-blind, controlled trial of 2849 patients at 74 centers.
Inclusion Criteria
Patients scheduled for endarterectomy for arteriosclerotic disease and tolerant of 1300 mg acetylsalicylic acid daily.
Exclusion Criteria
Participation in another trial, requiring acetylsalicylic acid or other antiplatelet medication prior to study, recent disabling stroke, cardiac surgery in previous 30 days or scheduled for cardiac surgery in the next 30 days, failure to provide informed consent.
Patient Involvement:
Patients were randomly assigned 81 mg (n=709), 325 mg (n=708), 650 mg (n=715), or 1300 mg (n=717) acetylsalicylic acid daily, started before surgery and continued for 3 months.
Primary Outcome:
Stroke, myocardial infarction, and death measured at 30 days and 3 months.
Results:
Patients treated with the two lower doses of aspirin before surgery had lower risk of stroke, heart attack or death at 30 days and three months following the surgery than did patients given the two higher doses. The combined rate of stroke, myocardial infarction and death was lower in the low-dose group than in the high-dose groups at 30 days (5.4% vs. 7.0%, p=0.07) and at 3 months (6.2% vs. 8.4%, p=0.03).
Source of Information:
Lancet. 1999 Jun 26;353(9171):2179-84.
|
|
Web Links and Publications:
|
|
This information last updated on: 9/26/2000
|
Trials
Directories