Acceleration of MCA-recanalization by transcranial ultrasound
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Status:
Trial complete. Results presented May 2003.
Purpose:
To examine the therapeutic effect of transcranial pulse-wave ultrasound in recanalization and the clinical outcome of patients suffering from acute occlusion of the middle cerebral artery not suitable for thrombolysis.
Year Presented:
2003
Design:
Randomized clinical trial.
Inclusion Criteria
Patients with acute occlusion of the middle cerebral artery admitted within 6 hours of onset and not suitable for thrombolytic therapy.
Patient Involvement:
Patients were randomized to either receive continuous ultrasound monitoring (n=8) or be in the control group (n=5).
Primary Outcome:
Recanalization and clinical outcome as measure by the NIHSS, modified Ranken Score, and Barthel Index.
Results:
The authors studied the effect of transcranial ultrasound on patients with acute middle cerebral artery occlusion and contraindications for thrombolysis. Fifteen consecutive subjects were randomized for insonation over 1 hour or for inclusion in a control group. By day 4, recanalization and neurologic improvement occurred more frequently in the target group. Ultrasound-induced acceleration of clot dissolution may be an option for patients with contraindications for recombinant tissue plasminogen activator.
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Source of Information:
Presented at 12th European Stroke Conference (May 2003).
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Web Links and Publications:
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This information last updated on: 7/22/2008
Reviewed on: 07/22/2008.
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