FIA
Familial Intracranial Aneurysm Study (Phase I)
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Status:
Phase I is active for follow-up only.
Purpose:
To identify possible genes that may increase the risk of stroke and particularly the development of aneurysms in blood vessels of the brain.
Location(s):
US, Canada, New Zealand, Australia
Year Started:
2002
Year Finished:
2009
Design:
Multicenter, retrospective and prospective, genome-wide linkage study.
Inclusion Criteria
Two or more affected pairs of siblings (brothers/sisters) or 3 or more family members affected with intracerebral aneurysms. Eligible families include: 1) Families with at least 2 living affected siblings, 2) Families with at least 2 affected siblings, one is living and the other whose genotype can be reconstructed, 3) Families with ≥ 3 affected non-sibling family members, two of whom both alive and have living connecting relatives, and 4) Families with > 3 affected, with one living and at least one other affected relative whose genotype can be reconstructed.
Exclusion Criteria
History of polycystic kidney disease, Marfan’s Syndrome, Ehler Danlos Syndrome, or fibromuscular dyslpasia.
Patient Involvement:
Participants will be asked to complete a family history questionnaire and a medical history questionnaire. They will also have their blood pressure measured and will give a small sample of blood. In addition, certain family members will be offered the opportunity to undergo a Magnetic Resonance Angiography MRA (a non-invasive diagnostic test) to look for undiagnosed brain aneurysms.
Additionally, participants will be contacted by mail on a yearly basis to evaluate their health, and to determine if any other family members have developed intracranial aneurysms.
Primary Outcome:
SNP genotyping; nonparametric (allele sharing) linkage analysis, including environmental risk factors is conducted; and fine gene mapping will be performed.
Results:
Phase I completed in 2009 and Phase II started.
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Source of Information:
Direct correspondence with trial coordinators.
Presented at the 30th International Stroke Conference [February 2005].
Presented at the 2006 International Stroke Conference [February 2006].
ClinicalTrials.gov
Presented at the 2007 International Stroke Conference [February 2007].
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Web Links and Publications:
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This information last updated on: 10/5/2009
Reviewed on: 09/29/2009.
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