Danish very-low-dose aspirin after carotid endarterectomy trial
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Status:
Trial complete. Results published 10/88.
Purpose:
To evaluate the effect of very-low-dose aspirin as an antithrombotic agent in patients who had recently undergone carotid endarterectomy.
Location(s):
Rigshospitaliet and Aaolborg, Denmark.
Design:
Randomized, double-blind trial of 301 patients at 2 centers.
Inclusion Criteria
Had already undergone elective carotid endarterectomy without sustaining an incapacitating neurologic deficit.
Exclusion Criteria
Residence too far away for follow-up, allergy to aspirin, necessary medication that affected platelet function, anticoagulation therapy lasting > 3 months, previous intracerebral hematoma, dementia, reluctance to participate.
Patient Involvement:
Patients were randomized to receive 50 mg of aspirin initially or placebo. If platelet inhibition was <80% compared to baseline after 2 months, it was measured again 1 week later and the aspirin dose was increased in 10-mg increments until satisfactory inhibition had been obtained. Some patients in the placebo group also had their doses adjusted at random with placebo tablets. Interviews and neurologic examinations were performed before and after surgery, 2 months after entry and every 6 months thereafter for an average of about 2 years.
Primary Outcome:
Platelet aggregation, amaurosis fugax, retinal infarction, transient ischemic attack, stroke, acute myocardial infarction, nonvascular death, vascular death.
Results:
There was no significant effect of very-low-dose aspirin.
Source of Information:
Stroke 1988 Oct;19(10):1211-5.
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This information last updated on: 3/2/2001
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