FIA II
Familial Intracranial Aneurysm Study (phase II)
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Status:
This study is ongoing, with active recruitment of participants.
Purpose:
To identify possible genes that may increase the risk of stroke and particularly the development of aneurysms in blood vessels of the brain.
Location(s):
United States, Canada
Year Started:
2009
Year Finished:
2011
Year Presented:
2010
Design:
Multicenter, retrospective and prospecting, genome-wide linkage study.
Inclusion Criteria
To be eligible to participate in this study, families must have two or more affected pairs of siblings (brothers/sisters) or 3 or more family members affected with intracranial aneurysms. Subjects can participate if they do not have an eligible family history, but do have a confirmed intracranial aneurysm.
Exclusion Criteria
History of polycystic kidney disease, Marfan’s Syndrome, Ehler Danlos Syndrome, Moya Moya or fibromusclar dysplasia.
Patient Involvement:
Participants will be asked to complete a family history questionnaire (if they have a family history) and a medical history questionnaire. They will also have their blood pressure measured and will give a small sample of blood. In addition, medical records will be requested to confirm the diagnosis of intracranial aneurysms. There will be no monetary compensation for participation.
Primary Outcome:
SNP Genotyping; nonparametic (allele sharing) linkage analysis, including environmental risk factors is conducted; and fine gene mapping will be preformed
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Source of Information:
ClinicalTrials.gov
Presented at 2010 International Stroke Conference (February 2010).
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Web Links and Publications:
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This information last updated on: 3/2/2010
Reviewed on: 03/09/2010.
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