Action
Surgical therapy to remove atherosclerotic plaque in narrowed carotid arteries.

Status
Major symptomatic and asymptomatic trials completed - see published studies. Clear benefit of endarterectomy in secondary prevention for symptomatic patients with >70% stenosis. Potential value of surgery for 50-69% (symptomatic) or 60-99% (asymptomatic) is smaller and depends on surgical morbidity.

Trial(s)
  = Ongoing
  = Completed

	ACAS	Asymptomatic Carotid Atherosclerosis Study
	ACE	Aspirin and Carotid Endarterectomy Trial
	ACST	Asymptomatic Carotid Surgery Trial
	ACT I	Carotid Stenting vs. Surgery of Severe Carotid Artery Disease and Stroke Prevention in Asymptomatic Patients
		Carotid Artery Stenting vs. Carotid Endarterectomy
		Carotid Endarterectomy and Contralateral Carotid Occlusion
	CASANOVA	Carotid Artery Stenosis with Asymptomatic Narrowing: Operation Versus Aspirin
	CAVATAS	Carotid and Vertebral Transluminal Angioplasty Study
	CREST	Carotid Revascularization Endarterectomy vs Stent Trial
	ECST	European Carotid Surgery Trial
	EVA-3S	Endarterectomy Versus Angioplasty in Patients with Severe Symptomatic Carotid Stenosis
	GALA	General anaesthetic versus local anaesthetic for carotid surgery
	ICSS (CAVATAS-2)	International Carotid Stenting Study
	MACE	Mayo Asymptomatic Carotid Endarterectomy Study Group
	NASCET	North American Symptomatic Carotid Endarterectomy Trial
		Prospective Randomized Trial of Carotid Endarterectomy Contralateral to Carotid Artery Occlusion
		Role of carotid endarterectomy in asymptomatic carotid stenosis: a Veterans Administration Cooperative Study.
	SAPPHIRE	Stenting and Angioplasty with Protection in Patients and HIgh Risk for Endarterectomy
		Silent Cerebral Infarcts After Carotid Endarterectomy Or Stenting And The Risk Of Cognitive Decline
	SPACE	Stent-protected Percutaneous Angioplasty of the Carotid vs. Endarterectomy
	VACSP 309	Carotid Endarterectomy and Prevention of Cerebral Ischemia in Symptomatic Carotid Stenosis

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