Stroke Trials Registry

Hypothermia
Brain cooling

Action
Reduction of brain temperature and body temperature for neuroprotection

Status
Controlled trials of hypothermia in stroke, cardiac and brain surgery are ongoing.

Trial(s)
= Ongoing
= Completed

CHILI Controlled Hypothermia in Large Infarction

CHIL The Cerebral Hypothermia in Ischaemic lesion (CHIL) Trial - A Randomised trial evaluating systemic and local mild hypothermia in Acute Ischaemic Stroke

COAST-II Cooling in acute Stroke-II

Combined Neuroprotective Modalities Coupled With Thrombolysis in Acute Ischemic Stroke: A Pilot Study of Caffeinol and Mild Hypothermia[SPOTRIAS]

COOL AID I Cooling Acute Ischemic Brain Damage - Safety and Feasibility Study

COOL AID Pilot Cooling Acute Ischemic Brain Damage - Pilot

COOL BRAIN-STROKE Cooling Helmet for Patients with Brain Ischemic and Hemorrhagic Infarctions

Hemicraniectomy and Moderate Hypothermia in Patients With Severe Ischemic Stroke

ICTuS-L Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke[SPOTRIAS]

IHAST1 Hypothermia and intracranial aneurysm surgery:part 1

IHAST2 Intraoperative Hypothermia for Aneurysm Surgery Trial, Part 2

Mild Hypothermia in Acute Ischemic Stroke: Safety and Feasibility Study

NOCSS Nordic Cooling Stroke Study

NOTHOT Normothermia and Stroke Outcome

Web Links and Publications

Hypothermia During Intracranial Aneurysm Surgery Trial.
ClinicalTrials.gov

Mannitol for acute stroke.
Cochrane Database Syst Rev. 2001;1:CD001153. Review.

Eversion versus conventional carotid endarterectomy for preventing stroke.
Cochrane Database Syst Rev. 2001;1:CD001921. Review.

Intraoperative Hypothermia for Aneurysm Surgery Trial.

Major ongoing stroke trials.

Major ongoing stroke trials.
Stroke 2002 Feb;33(2):646-55

Hemicraniectomy and Moderate Hypothermia in Patients With Severe Ischemic Stroke.
Stroke 2002 Jun;33(6):1584-8

Hypothermia to reduce neurological damage following coronary artery bypass surgery.
Cochrane Database Syst Rev. 2001;1:CD002138. Review.

Cooling for Acute Ischemic Brain Damage (COOL AID): Preliminary Efficacy Data of Moderate Hypthermia for Acute Ischemic Stroke. 26th International Stroke Conference.
Stroke 2001:32:336-c.

Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke.
Stroke 2001 Aug;32(8):1847-54

Radiant Medical Announces Approval of Stroke Clinical Trial with New Cooling Technology.

Cooling for Acute Ischemic Brain Damage (COOL AID): Preliminary Efficacy Data of Moderate Hypothermia For Acute Ischemic Stroke. 26th International Stroke Conference.
http://stroke-meeting.ahajournals.org/cgi/content/abstract/32/1/336-c

Cooling therapy for acute stroke.
Cochrane Database Systematic Review. 2000;2:CD001247

Neurochemical Monitoring of Therapeutic Hypothermia After Hemispheric Stroke.
Stroke 2000 31(1): 295

Controlled Rewarming in Moderate Hypothermia Improves Outcome in Stroke Patients with Hemispheric Edema.
Stroke 2000 31(1): 295

Moderate Induced Hypothermia Following Cardiac Arrest- a Safety and Feasibility Trial.
Stroke 2000 31(1): 284

Moderate hypothermia for the treatment of malignant middle cerebral artery infarct. [Article in German].
Nervenarzt 1999 Jun;70(6):539-46

Mild hypothermia as a protective therapy during intracranial aneurysm surgery: a randomized prospective pilot trial.
Neurosurgery. 1999 Jan;44(1):23-32; discussion 32-3.

This information last updated on: 02/13/2009

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