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PubMed
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Stroke Interventions in Clinical Trials
Printable Version
Aspirin (stroke prevention)
Acetylsalicylic acid

Action
Antiplatelet agent; inhibits thromboxane A2

Status
FDA Approved for use in stroke prevention and cardiovascular disease

Trial(s)
  = Ongoing
  = Completed

4C-DES The Comparison of Effects Between Increased Dose of Clopidogrel and Addition of Cilostazol
AAASPS African American Antiplatelet Stroke Prevention Study
ACE Aspirin and Carotid Endarterectomy Trial
ACTIVE - W Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events
ADONIS Aspirin Dose Optimized in Non-Cardioembolic Ischemic Stroke
AFASAK I Copenhagen Atrial Fibrillation, Aspirin, and Anticoagulation Study
AFASAK II Second Copenhagen Atrial Fibrillation, Aspirin, and Anticoagulation Study
AICLA Controlled trial of aspirin and dipyridamole in the secondary prevention of athero-thrombotic cerebral ischemia
AITIA Aspirin in Transient Ischemic Attacks
AMBDAP Dual antiplatelet therapy in the acute phase following stroke and transient ischaemic attack (TIA): which is the best regimen?
Amplified Benefit of Clopidogrel Versus Aspirin in Patients With Diabetes Mellitus
Anticoagulant vs anti-platelet therapy as prophylactic against cerebral infarction in transient ischemic attacks
APASS Antiphospholipid Antibodies and Stroke Study
ARCH Aortic Arch Related Cerebral Hazard
ARRIVE Aspirin to reduce the risk of initial vascular events trial
ASCEND A Study of Cardiovascular Events iN Diabetes
ASPECT-2 Antithrombotics in the Secondary Prevention of Events in Coronary Thrombosis-2
Aspirin and sulfinpyrazone in threatened stroke
ATIAIS Anturane TIA Italian Study
AVASIS Aspirin Versus Anticoagulants in Symptomatic Intracranial Stenosis.
BAFTA Birmingham Atrial Fibrillation Treatment of the Aged
CAPRIE Clopidogrel vs. Aspirin in Patients at Risk of Ischemic Events
CARESS Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis
CASANOVA Carotid Artery Stenosis with Asymptomatic Narrowing: Operation Versus Aspirin
CATHARSIS Cilostazol-Aspirin Therapy Against Recurrent Stroke With Intracranial Artery Stenosis
CHARISMA Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance
COGENT-1 Clopidogrel and the Optimization of Gastrointestinal Events
Danish Cooperative Study
Danish very-low-dose aspirin after carotid endarterectomy trial
Drug-Eluting Stents for the Treatment of Intracranial Atherosclerosis.
Dutch TIA Dutch TIA Study
EAFT European Atrial Fibrillation Trial
Efficacy and Safety Study of Cilostazol to Prevent Reoccurrence of Stroke
ESPRIT European / Australasian Stroke Prevention in Reversible Ischaemia Trial
ESPS-2 European Stroke Prevention Study
FASTER Fast Assessment of Stroke and Transient ischemic attack to prevent Early Recurrence - Pilot Study
HAEST Heparin in Acute Embolic Stroke Trial
JASAP Japanese Aggrenox Stroke Prevention versus Aspirin Program
JPAD Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes Trial
JPPP Japanese Primary Prevention Project with Aspirin
Long Term Open Follow-Up With H376/95 vs Warfarin
Low-dose acetylsalicylic acid (ASA) plus dipyridamole versus dipyridamole alone in stroke prevention
MATCH Management of ATherothrombosis with Clopidogrel in High-risk patients with recent TIA or ischemic stroke
NASPEAF National Study for Prevention of Embolism in Atrial Fibrillation
Persantine Aspirin Trial
PICSS Patent Foramen Ovale in Cryptogenic Stroke Study
PLUTO Clopidogrel and Aspirin versus Aspirin Alone in Stroke Patients
RAPCAPS Rural Andhra Pradesh Cardiovascular Prevention Study
RCS Recurrent Carotid Stenosis
RESPECT Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment
S-ACCESS Sarpogrelate Used as Preventive Therapy Against Recurrent Ischemic Events
SMART Standard Medical Management in Secondary Prevention of Ischemic Stroke in China
SPAF III Stroke Prevention in Atrial Fibrillation III
SPIRIT Stroke Prevention in Reversible Ischemia Trial
SPS3 Secondary Prevention of Small Subcortical Strokes [SPOTRIAS]
STRATAGEM Strategy for Managing Antiplatelet Therapy in the Peri-Operative Period of Non Coronary Surgery
Swedish Cooperative Study
TACIP Triflusal vs Acetylsalicylic Acid in Secondary Prevention of Cerebral Infarction
TAPIRSS Triflusal vs Aspirin for the Prevention of Infarction: Randomized Stroke Study
Ticlopidine Aspirin Stroke Study
TOSS-II Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis-II
UK-TIA United Kingdom Transient Ischaemic Attack Aspirin Trial
WARCEF Warfarin-Aspirin Reduced Cardiac Ejection Fraction Study [SPOTRIAS]
WARSS Warfarin-Aspirin Recurrent Stroke Study
WASID-R Warfarin-Aspirin Symptomatic Intracranial Disease Study - Retrospective
WASID Warfarin-Aspirin Symptomatic Intracranial Disease Study

Web Links and Publications
Aspirin (Salicylates) Patient Information.

Antithrombotic drugs for carotid artery dissection.
Cochrane Database Syst Rev. 2000;(4):CD000255. Review.

Oral anticoagulants versus antiplatelet therapy for preventing further vascular events after transient ischaemic attack or minor stroke of presumed arterial origin (Cochrane Review).
Cochrane Database Syst Rev. 2001;4:CD001342.

Anticoagulants or antiplatelet therapy for non-rheumatic atrial fibrillation and flutter.
Cochrane Database Syst Rev. 2001;1:CD001938. Review.

Antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks.
Cochrane Database Syst Rev. 2000;(2):CD001923.

Stroke Recurrence, Cognitive Impairment and White Matter Abnormalities are Frequent in Hispanic Americans with Lacunar Stroke.

Effect of Medical Treatment in Stroke Patients With Patent Foramen Ovale.
Circulation. 2002;105:2625

Data quality assurance and quality control measures in large multicenter stroke trials: the African-American Antiplatelet Stroke Prevention Study experience.
Curr Control Trials Cardiovasc Med 2001;2(3):115-117

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