Stroke Trials Registry

Remacemide

Action
Low-affinity NMDA receptor antagonist; also interacts with voltage-dependent sodium channels

Status
Trial in cardiac surgery patients reported improvement in overall neuropsychological scale for remacemide (n=87) or placebo (n=84, p=.028). Dose-escalation controlled trial in acute stroke published 1999.

Trial(s)
= Ongoing
= Completed

Web Links and Publications

AstraZeneca Web Site.

Remacemide hydrochloride: a double-blind, placebo-controlled, safety and tolerability study in patients with acute ischemic stroke.
Stroke 1999 Sep;30(9):1796-801.

Neuroprotection of the brain during cardiopulmonary bypass: a randomized trial of remacemide during coronary artery bypass in 171 patients.
Stroke 1998 Nov;29(11):2357-62

Initial experience with remacemide hydrochloride in patients with acute ischemic stroke.
Ann N Y Acad Sci 1995 Sep 15;765:322-3

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