Stroke Trials Registry

Aspirin (acute stroke)
Acetylsalicylic acid

Action
Antiplatelet agent; inhibits thromboxane A2

Status
Two large trials (IST, CAST) showed small (~ 1 %) but significant effect of early aspirin use in acute stroke.

Trial(s)
= Ongoing
= Completed

AIST Acute Ischemic Stroke Trial - Oral Aspirin vs Intravenous Heparin on Stroke Progression

ARTIS Antiplatelet therapy in combination with Recombinant t-PA Thrombolysis in Ischemic Stroke

CAIST Cilostazol in Acute Ischemic Stroke Treatment

CAST Chinese Acute Stroke Trial

CATALIST Combination Anti-platelet and Anti-coagulation Treatment After Lysis of Ischemic Stroke Trial [SPOTRIAS]

COMPRESS COMbination of Clopidogrel and Aspirin for Prevention of Early REcurrence in Acute Atherothrombotic Stroke

ECLIPse Effect of Cilostazol in the Acute Lacunar Infarction based on Pulsatility Index of Transcranial Doppler

FISS-tris Low-Molecular-Weight Heparin for Acute Stroke Patients with Large Artery Occlusive Disease

IST International Stroke Trial

MASH-1 Magnesium in Aneurysmal Subarachnoid Hemorrhage

MAST-I Multicentre Acute Stroke Trial-Italy

Oral Aspirin vs. Intravenous Heparin for Acute Ischemic Stroke Progression

SETIS Study of Efficacy of Tirofiban in Acute Ishemic Stroke

Study of Aspirin and TPA in Acute Ischemic Stroke

TAIST Tinzaparin in Acute Ischemic Stroke Trial

Web Links and Publications

Note: This is an abridged publications list. Click on a clinical trial name above for a full list of publications resulting from that trial.

Aspirin (Salicylates) Patient Information.

The results of CAPRIE, IST and CAST. Clopidogrel vs. Aspirin in Patients at Risk of Ischaemic Events. International Stroke Trial. Chinese Acute Stroke Trial.
Thromb Res. 1998 Sep 15;92(1 Suppl 1):S13-6.

UID: 5