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Stroke Interventions in Clinical Trials
Printable Version
Warfarin
Coumadin®

Action
Anticoagulant (Vitamin K antagonist)

Status
Warfarin is superior to aspirin for stroke prevention in atrial fibrillation is many settings. WARSS trial showed no benefit of warfarin compared to aspirin for non-cardioembolic stroke.

Trial(s)
  = Ongoing
  = Completed

Clinical and Economic Implications of Genetic Testing for Warfarin Management
ACAPS Asymptomatic Carotid Artery Plaque Study
ACTIVE - W Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events
AFASAK I Copenhagen Atrial Fibrillation, Aspirin, and Anticoagulation Study
AFASAK II Second Copenhagen Atrial Fibrillation, Aspirin, and Anticoagulation Study
AMADEUS Evaluating the use of SR34006 compared to Warfarin or Acenocoumarol in patients with atrial fibrillation
Anticoagulant vs anti-platelet therapy as prophylactic against cerebral infarction in transient ischemic attacks
APASS Antiphospholipid Antibodies and Stroke Study
ARCH Aortic Arch Related Cerebral Hazard
ARISTOTLE Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation
AVASIS Aspirin Versus Anticoagulants in Symptomatic Intracranial Stenosis.
BAATAF Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators
BAFTA Birmingham Atrial Fibrillation Treatment of the Aged
CADISS Cervical Artery Dissection In Stroke Study: Feasibility Phase.
CAFA Canadian Atrial Fibrillation Anticoagulation Study
Comparative study of the stability of oral anticoagulant therapy using phenprocoumon or warfarin.
CROWN Study to Develop a Reliable Warfarin-dosing Nomogram That Incorporates Clinical and Genetic Information
EAFT European Atrial Fibrillation Trial
ENGAGE - AF TIMI - 48 Global Study to Assess the Safety and Effectiveness of DU-176b vs Standard Practice of Dosing With Warfarin in Patients With Atrial Fibrillation
JNAF-ESP Japanese Nonvalvular Atrial Fibrillation-Embolism Secondary Prevention Cooperative Study
Long-term anticoagulation in stroke patients with atrial fibrillation
NASPEAF National Study for Prevention of Embolism in Atrial Fibrillation
PATAF Primary Prevention of Arterial Thromboembolism in Nonrheumatic Atrial Fibrillation
PERFORM Prevention of cerebrovascular and cardiovascular Events of ischaemic origin with teRutroban in patients with a history oF ischaemic strOke or tRansient ischaeMic attack
PICSS Patent Foramen Ovale in Cryptogenic Stroke Study
Prevention of Stroke and Systemic Embolic Events in Patients With Atrial Fibrillation
PRINT Prolongation of the interval between monitoring of Warfarin in stable patients
RE-LY Randomized Evaluation of Long Term Anticoagulant Therapy With Dabigatran Etexilate
RESPECT Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment
ROCKET AF Randomized, Double-Blind Study Comparing Once Daily Oral Rivaroxaban With Adjusted-Dose Oral Warfarin for the Prevention of Stroke in Subjects With Non-Valvular Atrial Fibrillation
SPAF III Stroke Prevention in Atrial Fibrillation III
SPAF II Stroke Prevention in Atrial Fibrillation II
SPINAF Veterans Affairs Stroke Prevention in Nonrheumatic Atrial Fibrillation Investigators
SPIRIT Stroke Prevention in Reversible Ischemia Trial
SPORTIF V Stroke Prevention by ORal Thrombin Inhibition V
WARCEF Warfarin-Aspirin Reduced Cardiac Ejection Fraction Study [SPOTRIAS]
WARSS Warfarin-Aspirin Recurrent Stroke Study
WASID-R Warfarin-Aspirin Symptomatic Intracranial Disease Study - Retrospective
WASID Warfarin-Aspirin Symptomatic Intracranial Disease Study
WAVE Warfarin and Antiplatelet Vascular Evaluation

Web Links and Publications
Note: This is an abridged publications list. Click on a clinical trial name above for a full list of publications resulting from that trial.
Anticoagulants Patient Information (MEDLINEplus).
PICSS
ClinicalTrials.gov
WASID Trial Web Site.
ClinicalTrials.gov
Antithrombotic drugs for carotid artery dissection.
Cochrane Database Syst Rev. 2000;(4):CD000255. Review.
Oral anticoagulants versus antiplatelet therapy for preventing further vascular events after transient ischaemic attack or minor stroke of presumed arterial origin (Cochrane Review).
Cochrane Database Syst Rev. 2001;4:CD001342.
Anticoagulants or antiplatelet therapy for non-rheumatic atrial fibrillation and flutter.
Cochrane Database Syst Rev. 2001;1:CD001938. Review.
Warfarin vs Aspirin Reduced Cardiac Ejection Fraction Study (WARCEF).
Ongoing Clinical Trials Session, 27th International Stroke Conference, 2002. [PDF Format]
Warfarin-Aspirin for Symptomatic Intracranial Disease (WASID).
Ongoing Clinical Trials Session, 27th International Stroke Conference, 2002. [PDF Format]
AVASIS - Aspirin Versus Anticoagulants in secondary prevention of vascular events in Symptomatic Intracranial Stenosis of the middle cerebral artery.
Ongoing Clinical Trials Session, 27th International Stroke Conference, 2002. [PDF Format]
Effect of medical treatment in stroke patients with patent foramen ovale: patent foramen ovale in cryptogenic stroke study.
Circulation 2002 Jun 4;105(22):2625-31
Effect of Medical Treatment in Stroke Patients With Patent Foramen Ovale.
Circulation. 2002;105:2625
Low-dose warfarin in rehabilitating stroke survivors.
Thrombosis Research 2002; 107:287-290.
A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. Warfarin-Aspirin Recurrent Stroke Study Group.
N Engl J Med 2001 Nov 15;345(20):1444-51.
Oral anticoagulants for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks.
Cochrane Database Syst Rev. 2000;(2):CD001927. Review.
Primary prevention of arterial thromboembolism in non-rheumatic atrial fibrillation in primary care: randomised controlled trial comparing two intensities of coumarin with aspirin.
BMJ. 1999 Oct 9;319(7215):958-64.
Patients with nonvalvular atrial fibrillation at low risk of stroke during treatment with aspirin: Stroke Prevention in Atrial Fibrillation III Study. The SPAF III Writing Committee for the Stroke Prevention in Atrial Fibrillation Investigators.
JAMA 1998 Apr 22-29;279(16):1273-7
The Warfarin-Aspirin Symptomatic Intracranial Disease Study.
Neurology. 1995 Aug;45(8):1488-93.
Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation. Veterans Affairs Stroke Prevention in Nonrheumatic Atrial Fibrillation Investigators.
N Engl J Med. 1992 Nov 12;327(20):1406-12.
The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation. The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators.
N Engl J Med 1990 Nov 29;323(22):1505-11.
This information last updated on: 12/26/2008

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