Stroke Trials Registry

Transfusion

Action
Blood exchange for stroke prophylaxis in sickle cell anemia

Status
Multi-center STOP trial was halted in September, 1997 when interim analysis showed strong benefit for transfusion therapy in children with sickle cell anemia. STOP 2 trial underway.

Trial(s)
= Ongoing
= Completed

SIT Silent Infarct Transfusion Study

STOP II Optimizing Primary Stroke Prevention in Sickle Cell Anemia

STOP Stroke Prevention in Sickle Cell Anemia

SWiTCH Stroke With Transfusions Changing to Hydroxyurea

Web Links and Publications

STOP II Web Site

Chlamydia, Sickle Cell Anemia and Stroke Risk - Ancillary to STOP II.
ClinicalTrials.gov

STOP 2 Trial Information
ClinicalTrials.gov

Longitudinal changes in ferritin during chronic transfusion: a report from the Stroke Prevention Trial in Sickle Cell Anemia (STOP).
J Pediatr Hematol Oncol 2002 May;24(4):284-90

Prospective RBC phenotype matching in a stroke-prevention trial in sickle cell anemia: a multicenter transfusion trial.
Transfusion 2001 Sep;41(9):1086-92

Impact of chronic transfusion on incidence of pain and acute chest syndrome during the Stroke Prevention Trial (STOP) in sickle-cell anemia.
J Pediatr 2001 Dec;139(6):785-9

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