Action
E-selectin is a cell surface receptor that is expressed by endothelial cells and mediates the binding of various white blood cells (leukocytes), including neutrophils, monocytes and some types of memory T cells, to the endothelial cells. Leukocyte adhesion to endothelial cells is a critical step in the migration of a leukocyte out of a blood vessel and into a tissue. Leukocytes are an important component of inflammatory and immunological responses.

Status

Trial(s)
  = Ongoing
  = Completed

Induction of mucosal tolerance to E-selectin for the secondary prevention of stroke

UID: 340