Stroke Trials Registry

Magnesium

Action
Ion channel blocker (blocks voltage gated calcium channels and NMDA receptors)

Status
Multicenter UK trial of IV magnesium (IMAGES) ongoing.

Trial(s)
= Ongoing
= Completed

FAST-MAG Pilot Study Field Administration of Stroke Therapy-Magnesium

FAST-MAG Field Administration of Stroke Therapy - Magnesium Phase III Trial

IMAGES Intravenous MAGnesium Efficacy in Stroke

IMASH Intravenous Magnesium Sulfate in Aneurysmal Subarachnoid Hemorrhage

MASH-1 Magnesium in Aneurysmal Subarachnoid Hemorrhage

MASH-II Magnesium in Aneurysmal Subarachnoid Hemorrhage (MASH-II)

MR IMAGES Magnetic Resonance in Intravenous Magnesium Efficacy in Stroke Trial: MR Images

Randomized, Double-Blind, Placebo-Controlled Pilot Trial of Intravenous Magnesium Sulfate in Acute Stroke

Web Links and Publications

Magnesium Supplements Patient Information (MEDLINE plus).

IMAGES Trial Web Site

Field Administration of Stroke Therapy - Magnesium (FAST-MAG) Trial
ClinicalTrials.gov

Prehospital Neuroprotective Therapy for Acute Stroke: Results of the Field Administration of Stroke Therapy-Magnesium (FAST-MAG) Pilot Trial.
Stroke 2004;

Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial
Lancet. 2004; 363: 439-45.

News about neuroprotectants for the treatment of stroke.
JAMA 2002 Mar 13;287(10):1253-4

Major ongoing stroke trials.
Stroke 2002 Feb;33(2):646-55

Magnesium and Acetylsalicylic Acid in Subarachnoid Hemorrhage (MASH), a Prospective Randomized, Placebo-Controlled, Multicenter Trial.
Ongoing Clinical Trials Session, 27th International Stroke Conference, 2002. [PDF Format]

The Field Administration of Stroke Therapy - Magnesium (FAST-MAG) Phase 3 Trial.
Ongoing Clinical Trials Session, 27th International Stroke Conference, 2002. [PDF Format]

IMAGES - Intravenous Magnesium Efficacy in Stroke Trial. IMAGES Study Group. Ongoing Clinical Trials Session, 25th International Stroke Conference.
Ongoing Clinical Trials Session, 25th International Stroke Conference.

Magnetic Resonance in Intravenous Magnesium Efficacy in Stroke Trial (MR IMAGES). Ongoing Clinical Trials Session, 25th International Stroke Conference.
Ongoing Clinical Trials Session, 25th International Stroke Conference.

New experimental and clinical data on the efficacy of pharmacological magnesium infusions in cerebral infarcts.
Magnes Res 1998 Mar;11(1):43-56

Dose optimization of intravenous magnesium sulfate after acute stroke.
Stroke 1998 May;29(5):918-23

A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke.
Stroke 1995 Jul;26(7):1183-8

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