Stroke Trials Registry

Heparin (acute stroke)

Action
Intravenous anticoagulant.

Status
Heparin is widely used in acute stroke, but no randomized clinical trials support this use.

Trial(s)
= Ongoing
= Completed

AIST Acute Ischemic Stroke Trial - Oral Aspirin vs Intravenous Heparin on Stroke Progression

AUST Australian Urokinase Stroke Trial

CADISS Cervical Artery Dissection In Stroke Study: Feasibility Phase.

Early heparin therapy in patients with spontaneous intracerebral hemorrhage

Enoxaparin vs heparin for prevention of deep-vein thrombosis in acute ischaemic stroke: a randomized, double-blind study.

Heparin treatment in sinus venous thrombosis

High-Dose IV Unfractionated Heparin vs. Aspirin in Acute Ischemic Stroke

Intravenous Heparin for the Prevention of Stroke Progression in Acute Partial Stable Stroke.

IST International Stroke Trial

Oral Aspirin vs. Intravenous Heparin for Acute Ischemic Stroke Progression

PREVAIL PREvention of VTE after Acute Ischemic Stroke with LMWH or Enoxaparin.

Randomized trial of aspirin or heparin in hospitalized patients with recent transient ischemic attacks

Randomized trial of immediate anticoagulation of embolic stroke

RAPID Rapid Anticoagulation Prevents Ischemic Damage

Safety and Efficacy of Low-dose Heparin During Intracranial Angioplasty and Stent Placement

Web Links and Publications

Heparin Patient Information (MEDLINEplus).

Low-molecular-weight heparins or heparinoids versus standard unfractionated heparin for acute ischaemic stroke (Cochrane Review).
Cochrane Database Syst Rev. 2001;4:CD000119.

Oral Aspirin vs. Intravenous Heparin for Acute Ischemic Stroke Progression. XVII World Congress of Neurology.
JNS Volume 187, Supplement 1, page S258, June 2001.

Anticoagulants for preventing recurrence following ischaemic stroke or transient ischaemic attack.
Cochrane Database Syst Rev 2000;(2):CD000248

A multicentre, double-blind, randomized study to compare the safety and efficacy of once-daily ORG 10172 and twice-daily low-dose heparin in preventing deep-vein thrombosis in patients with acute ischaemic stroke.
Age Ageing 1994 Nov;23(6):512-6.

Heparin treatment in sinus venous thrombosis.
Lancet 1991 Sep 7;338(8767):597-600.

Early heparin therapy in patients with spontaneous intracerebral haemorrhage.
J Neurol Neurosurg Psychiatry 1991 May;54(5):466-7.

A randomized trial of aspirin or heparin in hospitalized patients with recent transient ischemic attacks. A pilot study.
Stroke 1989 Apr;20(4):441-7.

Intravenous heparin for the prevention of stroke progression in acute partial stable stroke.
Ann Intern Med 1986 Dec;105(6):825-8.

Immediate anticoagulation of embolic stroke: a randomized trial. Cerebral Embolism Study Group.
Stroke 1983 Sep-Oct;14(5):668-76.

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