Action
Anti-pyretic analgesic; potent inhibitor of hemoprotein-catalyzed lipid peroxidatrion with an IC50 for hemoglovin of 15uM, which is in the range of plasma levels resulting from therapeutic doses of the drug in humans. It acts by reducing the ferryl-oxo radical form of the heme, and thereby prevents formation of the hemoprotein radical that initiates lipid peroxidation.

Status
In pilot studies to reduce body temperature during acute stroke.

Trial(s)
  = Ongoing
  = Completed

		Acetaminophen in aSAH to Inhibit Lipid Peroxidation and Cerebral Vasospasm
		Acetaminophen for Altering Body Temperature in Acute Stroke
	NOTHOT	Normothermia and Stroke Outcome
	PAIS	Paracetamol (acetaminophen) in stroke
		Paracetamol on body temperature in acute ischemic stroke
	PISA	Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke
		Prevention of fever with antipyretics after acute ischemic stroke

UID: 137