Action
Antiplatelet agent

Status
Phase III trial (CAPRIE) results published in 1996. The United States FDA granted marketing clearance 11/97 to Sanofi and Bristol-Myers Squibb’s Plavix(R) (clopidogrel bisulfate) for the reduction of atherosclerotic events (myocardial infarction, stroke, vascular deaths) in patients with atherosclerosis documented by recent myocardial infarctions, recent stroke or established peripheral arterial disease.

Trial(s)
  = Ongoing
  = Completed

	4C-DES	The Comparison of Effects Between Increased Dose of Clopidogrel and Addition of Cilostazol
		A Study of the Onset and Offset of Antiplatelet Effects Comparing AZD6140, Clopidogrel, and Placebo With Aspirin
	ACTIVE - W	Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events
	ACTIVE-A	Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events
	AMBDAP	Dual antiplatelet therapy in the acute phase following stroke and transient ischaemic attack (TIA): which is the best regimen?
		Amplified Benefit of Clopidogrel Versus Aspirin in Patients With Diabetes Mellitus
	ARCH	Aortic Arch Related Cerebral Hazard
	ASSIST II	Stent-assisted Angioplasty of the Offending Intracranial Stenosis plus Optimal Medical Therapy versus Optimal Medical Therapy Alone
	CADISS	Cervical Artery Dissection In Stroke Study: Feasibility Phase.
	CAPRIE	Clopidogrel vs. Aspirin in Patients at Risk of Ischemic Events
	CARESS	Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis
	CHARISMA	Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance
	CLASS-CHINA	Clopidogrel of loading dosage to treat acute ischaemic stroke in China
	COGENT-1	Clopidogrel and the Optimization of Gastrointestinal Events
	COMPRESS	COMbination of Clopidogrel and Aspirin for Prevention of Early REcurrence in Acute Atherothrombotic Stroke
		Drug-Eluting Stents for the Treatment of Intracranial Atherosclerosis.
	FASTER	Fast Assessment of Stroke and Transient ischemic attack to prevent Early Recurrence - Pilot Study
		Long Term Open Follow-Up With H376/95 vs Warfarin
	MATCH	Management of ATherothrombosis with Clopidogrel in High-risk patients with recent TIA or ischemic stroke
	PLATO	A Comparison of AZD6140 and Clopidogrel in Patients With Acute Coronary Syndrome
	PLUTO	Clopidogrel and Aspirin versus Aspirin Alone in Stroke Patients
	POINT	Platelet-Oriented Inhibition in New Transient Ischemic Attack (TIA) (POINT) Trial
	PRoFESS	Prevention Regimen For Effectively avoiding Second Strokes
	RESPECT	Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment
	SPS3	Secondary Prevention of Small Subcortical Strokes [SPOTRIAS]
	TACET	The Austrian Paradoxical Cerebral Embolism Trial
	TARDIS	Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke
	TOSS-II	Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis-II
	TRITON-TIMI 38	A Comparison of CS-747 and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention
	VAST	Vertebral Artery Stenting Trial
	WingspanSSIR	Wingspan Stenting for Symptomatic Severe Stenosis of Intracranial Atherosclerosis Registry in China

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