Stroke Trials Registry

Clomethiazole
Zendra®

Action
GABA agonist

Status
Phase II trial (CLASS) results published 1999. Phase III trials CLASS-I, CLASS-H, CLASS-T) completed 2000. Development of clomethiazole halted 11/00 when CLASS-I trial showed no effect in patients with ischemic stroke.

Trial(s)
= Ongoing
= Completed

CLASS Clomethiazole Acute Stroke Study

CLASS-IHT Clomethiazole Acute Stroke Study in Ischemic, Hemorrhagic, and tPA-treated Patients

Web Links and Publications

AstraZeneca Web Site.

The Clomethiazole Acute Stroke Study in tissue-type plasminogen activator-treated stroke (CLASS-T): final results.
Neurology. 2001 Oct 9;57(7):1199-205.

Results in 95 hemorrhagic stroke patients included in CLASS, a controlled trial of clomethiazole versus placebo in acute stroke patients.
Stroke 2000 Jan;31(1):82-5.

Clomethiazole (Zendra) in acute ischemic stroke: basic pharmacology and biochemistry and clinical efficacy.
Pharmacol Ther 1998 Nov;80(2):123-47

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