Thrombus Formation II–Platelet Activation and Blood Flow

Under high fluid shear-stress conditions, there is evidence that platelet aggregation depends on the binding of vWF (indicated in blue) to platelet GPIIb/IIIa [D’Souza E, et al, 1994; Moake JL, et al. J Clin Invest. 1986;78:1456-61]. It has also been shown that blockade of vWF-GPIIb/IIa interaction inhibits platelet aggregation and thrombus formation without disturbing the initial platelet adhesion [Aleviadou RB, et al. Blood. 1993;81:1263].

Thus, vWF appears to play a crucial role in both platelet adhesion and platelet aggregation under high shear-stress conditions, such as turbulent blood flow in atherosclerotic vessels. The importance of vWF is further supported by an association between elevated vWF concentrations and arterial thrombosis [Jansson HH, et al. Br Heart J. 1991;66:351].

Acute Ischemic Stroke: New Concepts of Care
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