Role of Platelets

Platelet AdhesionPlatelet aggregation and thrombosis after Type II injury are thought to play key roles in the progression of atherosclerosis. Platelet adhesion may be promoted by toxic products released by macrophages and by moderate damage to the intimal surface with denudation of the epithelium [Ip JH, et al, 1994].

Platelets release growth factors that stimulate migration and proliferation of smooth muscle cells and also contribute to the formation of subendothelial “fibrointimal lesions” and possibly to the formation of the outside capsule of predominantly “fatty lesions”.


Credits
Acute Ischemic Stroke: New Concepts of Care
The presentation of this content is made possible with permission from Genentech, Inc.
Copyright 1998-1999 Genentech Inc., all rights reserved. Content may not be reproduced without permission.