Thursday, March 21, 2002

Opening Reception

7:00—9:00 pm

Friday, March 22, 2002

Welcome

8:00—8:15 am

• Justin Zivin  
• John Marler  
• Tom Jacobs

What's Cool in Stroke Therapy
Chair: Pat Lyden

8:15—10:00 am

• Pat Lyden
  Introduction
  Hyperthermia and Molecular Mechanisms of Hypothermia
• Midori Yenari
  Therapeutic Hypothermia Animal Models
• Derk Krieger
  Pilot Human Trials

Ischemic Preconditioning and Transcription Factors
Co-Chairs: Stuart Lipton & Raj Ratan

10:30—12:15 pm

• Stuart Lipton
  Erythropoietin as an ischemic preconditioning factor in the brain
• Chung Hsu
  Differential roles of NF-kappaB and AP-1after transient forebrain ischemia
• Raj Ratan
  Neuroprotection involving the transcription factors HIF-1 and ATF-1/CREB

Matrix Metalloproteinase Expression and Inhibition
Co-Chairs: Frank Marcoux & Jerry Schielke

1:30—3:15 pm

• Robert Newton
  Metalloproteases
• Gary Rosenberg
  MMP and TIMP Expression in Brain Ischemia
• Yvan Gasche
  MMP Inhibition in Brain Ischemia

Neurovascular Processes in Ischemic Brain Injury
Chair: Greg del Zoppo

3:45—5:30 pm

• Eng Lo
  Mechanisms of Matrix Degradation
• Greg del Zoppo
  Neuron and Microvascular Matrix/Protease Compartmentalization
• Bruce Ransom
  Responses of White Matter to Ischemic Injury
• Tika Benveniste
  Microvascular responses in a Cytokine Milieu
• Kyra Becker
  Vasculars Roles in Leukocyte Infiltration
• Constantio Iadecola
  Inflammatory Responses of the Brain Parenchymal

After Dinner Talk

• Roger Porter
  Scientific Motivation and Conflict of Interest in Research

Saturday March 23, 2002

Enhancing Clot Lysis and Limiting Hemorrhage
Co-Chairs: Jim Grotta & Clarke Haley

8:00—9:45 am

• Desire Collen
  Novel Approaches to Fibrinolysis for Stroke
• Abd Higazi
  Strategies for improving on TPA for treating acute stroke
• Jim Grotta
  Coupling thrombolysis with other complementary strategies
• Clarke Haley
  Clinical Trials of New Lytic Drugs
• Stefan Mayer
  Limiting Hemorrhage Enlargement

Mitochondria-integrations or Neurotoxicity in Stroke
Co-Chairs: Valina Dawson & Gary Fiskum

10:15—12:00 pm

• Valina Dawson
  Apoptosis Inducing Factor in PARP-1 Mediated Excitotoxicity  
• J. Marie Hardwick
  Conversion of Anti-apoptotic Factors to Pro-apoptotic Factors in Neurons  
• Nissim Hay
  Interactions of Akt/PKB with Glycolysis and Mitochondrial Hexokinase in Cytoprotection  
• Mirella Gonzalez-Zulueta
  Mitochondrial Uncoupling Protein-2 in Preconditioning and Stroke

Genomic Strategies
Co-Chairs: Giora Feuerstein & Chung Hsu

1:15—3:00 pm

• Ulrich Dirnagl
  The SAGE Saga
• Valina Dawson
  Microarrays for Academics
• Giora Feuerstein
  Targeted Discovery of Disease Associated Genes

Adult Neurogenesis after Stroke
Co-Chairs: Mike Chopp & Olle Lindvall

3:30—5:15 pm

• Frank Sharp
• Steven Cramer
• Evan Snyder
• Jack Parent
• Olle Lindvall
• Mike Chopp

After Dinner Talk

• Jon Clark
  Adaptation, Maladaptation, Readaptation: Lessons Learned from the Human Space Flight Experience