Friday, March 10, 2000

Welcome

2:00—2:05 pm

Gerald D. Fischbach
The NINDS Mission in the New Millennium

2:05—2:20 pm

Oxidative Stress
Co-Chairs: raymond A. Swanson/Bo K. Siesjö

2:20 – 3:50 pm

• Joseph S. Beckma
  Contrasting Roles of Nitric Oxide and Peroxynitrite in Apoptotic Death of neurons
• Costantino Iadecola
  Interactions Between Cyclooxygenases and Nitric Oxide Synthases in the Development of ischemic Brain Injury
• Valina L. Dawson
  What Doesn’t Kill You Makes You Stronger: Pathways to Ischemic Tolerance
• Eugene M. Johnson
  Neuronal Death Caused by SOD Deletion: Role of Bax Interactive Discussion

Gene Transfer and Therapy
Co-Chairs: Gary K. Steinberg/Nicolas G. Bazan

4:20 – 5:50 pm

• Helen M. Blau
  Tales of VEGF: Angiogenesis versus Vasculogenesis
• Lorris Betz
  Issues Related to the Development of Adenoviral Vectors for Gene Therapy in Stroke
• Koji Abe
  Gene Therapy of Ischemic Brain with Adenovirus-Mediated Expression of a Neurotrophic Factor
• Donald D. Heistad
  Gene Transfer of CGRP, SODs and iNOS to Cerebral Blood Vessels
• Interactive Discussion

Clinical Trials
Co-Chairs: Gregory W. Albers/Marc Fisher

7:20 – 9:05 pm

• Thomas Brott
  Clinical Trials of Thrombolytic Therapy for Acute Stroke
• James Grotta
  Combination Therapies for Treatment of Acute Stroke
• Kennedy R. Lees
  Current Status of Neuroprotective Therapy for Acute Ischemic Stroke
• Interactive Discussion

Saturday, March 11, 2000

Apoptosis
Co-Chairs: Robert M. Sapolsky/Chung Hsu

8:00—9:30 am

• Stuart A. Lipton
  Role of a Novel Family of NMDA Receptor Subunits, NR3, in Protection from Hypoxic- Ischemic Injury
• Dale Bredesen
  A Novel Form of Cell Death and its Implications for Neurological Disease
• Mark P. Goldberg
  White Matter Ischemia
• Roger P. Simon
  Apoptotic Gene Expression in Brain Ischemia and ischemic Tolerance
• Interactive Discussion

Inflammation, BBB, Cytokines
Co-Chairs: Midori A. Yenari/Michael Chopp

10:00 – 11:30 am

• Giora Feuerstein
  Inflammation and Stroke: it’s All About Which, Where and When
• John M. Hallenbeck
  TNF-a in Ischemic Tolerance
• Nancy J. Rothwell
  Sites and Pathways Involved in IL-1 Actions in the Brain
• Gregory J. del Zoppo
  Protease Generation, Inflammation and Cerebral Microvascular Activation
• Interactive Discussion

Hot Topics
Co-Chairs: Rona G. Giffard/Myron D. Ginsberg

12:45 – 2:15 pm

• Nicolas G. Bazan
  Stress-Sensitive Kinases and Neuroprotection in Focal Cerebral Ischemia
• Maiken Nedergaard
  Cell–Cell Signaling
• Geoffrey Manley
  Aquaporin-4 in Brain Edema
• Jari Koistinaho
  Minocycline
• Interactive Discussion

Hemorrhage, Edema, Secondary Injury
Co-Chairs: Philip R. Weinstein/Bryce Weir

2:45 – 4:15 pm

• Gary A. Rosenberg
  Proteolytic Tissue Disruption by Matrix Metalloproteinases in Stroke
• Ross Bullock
  Neurochemical Events and Substrate Delivery in Severe Subarachnoid Hemorrhage: Can neuromonitoring Improve Outcome?
• Eng H. Lo
  tPA in Hemorrhage
• Konstantin-Alexander Hossmann
  Mechanisms of Infarct Evolution After Transient and Permanent Middle Cerebral Artery Occlusion in Mice
• Interactive Discussion

MRI in Clinical Stroke
Co-Chairs: Michael E. Moseley/Gregory W. Albers

4:45 – 6:15 pm

• Steven Warach
  MRI in Stroke Trials
• Jeffrey Saver
  Can MR Predict the Need for and Efficacy of Thrombolysis?
• Michael P. Marks
  Diffusion and Perfusion MRI in the Evaluation of Acute Ischemic Stroke
• Olaf Jansen
  Early Recanalization Saves Tissue at Risk as Defined by Stroke MRI
• Interactive Discussion

Lectures
Moderator: Richard J. Traystman

8:20 – 9:10 pm

• Dennis W. Choi
  Zinc and Ischemic Neuronal Death
• Michael A. Moskowitz
  Brain and Spinal Cord Ischemia: Diversity Among the Caspases

Sunday, March 12, 2000

Neurogenesis and Plasticity
Co-Chairs: Frank R. Sharp/Justin A. Zivin

8:00—9:30 am

• Evan Y. Snyder
  Ischemic CNS Injury May Direct Neural Stem Cells Towards Repopulation
• Jialing Liu
  Neuroplasticity after Cerebral Ischemia
• Michael M. Merzenich
  Plasticity Contributing to Recovery from Stroke
• Barbro B. Johansson
  Environmental Effects on Recovery from Stroke
• Interactive Discussion

Risk Factors and New Therapeutic Horizons
Co-Chairs: Vladimir Hachinski/John R. Marler

10:00 – 11:30 am

• Vladimir Hachinski
  Vascular Factors in Alzheimer’s Disease and Stroke
• James McCulloch
  Therapeutic Strategies Targeting White Matter
• Justin A. Zivin
  Basic Research and Stroke Therapeutics: What Have We Learned?
• John R. Marler
  Perspectives and New Horizons in Clinical Trials
• Interactive Discussion

Concluding Remarks
Gary K. Steinberg

11:30 – 11:35 am