Friday, May 8, 1998

Welcome
Dennis W. Choi, MD, PhD

NIH/NINDS challenge: New opportunities and initiatives
Gerald D. Fischbach MD, and Michael D. Walker, MD

Extracranial-intracranial bypass surgery: Time for a new clinical trial?
Chairs: Ralph G. Dacey Jr. and William J. Powers

• Ralph G. Dacey Jr., MD
  Introduction / frame
• Robert L. Grubb Jr., MD
  Cerebral hemodynamics and stroke risk
• Marc R. Mayberg, MD
  Surgical considerations
• Henry J.M. Barnett, MD
  Do we need another trial?
• William J. Powers, MD
  Interactive Discussion

Mediators and modulators of ischemic injury: Hot topics
Chairs: Richard J. Traystman and Peter Lipton

• Richard J. Traystman, PhD
  Introduction / frame
• Valina L. Dawson, PhD
  NO, PARP
• Pak H. Chan, PhD
  SOD
• Patricia D. Hurn, PhD
  Estrogen
• Michael Moskowitz, Peter Lipton, PhD
  Interactive Discussion

White matter ischemia - unique mechanisms of injury?
Chairs: Mark P. Goldberg and Vladimir Hachinski

• Mark P. Goldberg, MD
  Introduction / frame: Clinical and research problems in white matter stroke
• Julio H. Garcia, MD
  Neuropathology of white matter ischemia
• Stephen A. Back, MD, PhD
  Oligodendrocyte death in the developing brain
• Peter K. Stys, MD
  Mechanisms of ischemic axonal injury
• Marie-Germaine Bousser, PhD
  Update on CADASIL: what can we learn about white matter stroke?
• Vladimir Hachinski, MD
  Interactive Discussion

Inflammation
Chairs: John M. Hallenbeck and Michael Chopp

• John M. Hallenbeck, MD
  Introduction / frame
• Mark Fisher, MD
  Infection as a risk factor for stroke
• Gregory J. del Zoppo, MD
  Extracellular Matrix
• Chung Y. Hsu, MD, PhD
  Counter Point
• Michael Chopp, MD
  Interactive Discussion

Plenary lecture:
Free radicals and ischemic brain injury
Bo K. Siesjo, MD, PhD

Dinner Debate:
Heparin should be used to treat patients presenting with acute stroke or stroke-in-evolution
Moderator: Michael N. Diringer, MD

• Louis R. Caplan, MD (affirmative)
• William Powers, MD (negative)

Saturday, May 9, 1998

Beyond diffusion: imaging measurements of cerebral blood flow and metabolism
Chairs: Marc Fisher and Justin A. Zivin

• Marc Fisher, MD
  Introduction/frame
• Jean-Claude Baron, MD
  Cerebral blood flow and metabolism in acute stroke: What PET has taught us
• E. Mark Haacke, PhD
  Quantifying brain oxygenation with MR
• Alan C. McLaughlin, PhD
  Quantitative measurement of regional with arterial spin tagging
• Bruce R. Rosen, MD, PhD
  Measurement of cerebral perfusion by magnetic resonance with intravascular contrast agents
• Justin A. Zivin , MD, PhD
  Interactive Discussion

Molecular mechanisms of apoptosis
Chairs: Matthew D. Linnik and Michael A. Moskowitz

• Matthew D. Linnik, PhD
  Introduction/frame
• Michael O. Hengartner, PhD
  View from the worm
• Stanley J. Korsmeyer, MD
  Regulation of apoptosis
• Michael A. Moskowitz, MD
  Interactive Discussion

Delayed neuronal death
Chairs: William A. Pulsinelli and Myron D. Ginsberg

• William A. Pulsinelli, MD, PhD
  Introduction/frame
• R. Suzanne Zukin, MD
  Changes in glutamate receptor expression
• Hannah Monyer, MD
  Regulation of GluRB expression
• John A. Connor, PhD
  Late changes in neuronal Ca
• Myron D. Ginsberg, MD
  Interactive Discussion

Cortical reorganization and post-acute stroke treatment
Chairs: Larry B. Goldstein and Alexander W. Dromerick

• Larry B. Goldstein, MD
  Introduction/frame
• Randolph J. Nudo, PhD
  Adaptive plasticity in motor cortex
• Seth P. Finklestein, MD
  Growth factors and recovery
• Timothy J. Schallert, PhD
  Neuronal events in recovery after injury
• Alexander W. Dromerick, MD
  Interactive Discussion

Update: Recent Clinical Trials of Drug Treatments for Stroke
Greg Albers, MD

Plenary lecture:
CNS Stem cells: Biology and potential utility for promoting recovery
Fred H. Gage, PhD

Dinner Debate:
MRI is a good endpoint for determining the efficacy of stroke treatment trials
Moderator: Edward M. Manno, MD

• Steven J. Warach, MD, PhD (affirmative)
• Joseph P. Broderick, MD (negative)

Sunday, May 10, 1998

Directions for the future: where should we go?
Moderators: Dennis W. Choi and Murray Goldstein, DO, MPH)

• Invited presentations from meeting participants
• Discussion
• Panel:
  • Pak H. Chan, PhD
  • Fletcher H. McDowell, MD
  • J.P. Mohr, MD
  • Gary K. Steinberg, MD, PhD
  • Michael D. Walker, MD
  • Justin A. Zivin, MD, PhD