Evidence-Based
Use of Antithrombotic Therapy
in the Prevention of Cardioembolic Stroke Allyson Zazulia, M.D. -- Department
of Neurology and Radiology
Washington University School of Medicine -- Presented July
18, 2006
Cerebral venous thrombosis
agent
mean
time
to treat
good
outcome
p
Einhaupl
et al
1991*
IV
Heparin
(PTT 80-100
v. placebo)
30
days
at
3 mo:
hep 8/10
plac 1/10
<.01
De
Bruijn & Stam 1999
nadroparin
x 3 wk warfarin vs. placebo
10
days
at
3 wk:
nadro 24/30
plac 22/29
NS
+ /- benefit
* trial stopped at
pre-determined interim analysis
