William J. Powers, M.D.--Departments of
Neurology, Neurosurgery and Radiology
Washington University School of Medicine -- Presented July
11, 2006
Translating Evidence into Patient Care
How to Decide on the Applicability of
Clinical Trial Results to Your Patients
Issues
Biologic
(1) Are there pathophysiologic differences in the
illness under study that may lead to a diminished
treatment response?
(2) Are there patient differences that may diminish
the treatment response?
Social and economic
(3) Are there important differences in
patient compliance
that may diminish the treatment response?
(4) Are there important differences in provider compliance
that may diminish the treatment response?
Epidemiologic
(5) Do my patients have co-morbid conditions that
significantly alter the potential benefits and risks
of the treatment?
(6) Are there important differences in untreated patients'
risk of adverse outcomes that might alter the efficiency
treatment?
